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KMID : 0380319850360000133
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Journal of Korean Research Institute for Better Living
1985 Volume.36 No. 0 p.133 ~ p.142
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Abstract
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It has been reported that clonidine is α_2-adrenergic agonist, potent new hypotensive drug in human with low dose. The change in blood pressure is implicated in the concentration, release, uptake and metabolism of catecholamine, neurotransmitter in specific brain areas.
Thus the experiment was set up to investigate the effect of clonidine alone and that of clonidine pretreated with imipramine or tranylcypromine on the catecholamine change by measuring epinephrine and norepinephrine content in brain and adrenal gland.
The norepinephrine content in hypothalamus and brainstem is increased by intraperitoneally administered clonidine 0.1mg/kg twice a day for 5 days, but decreased in the rats pretreated with imipramine 10mg/kg intraperitoneally given 26 hrs. and 5hrs. before decapitation. However the norepinephrine content in region of brain is not changed in rats pretreated with tranylcypromine 10mg/kg intraperitoneally twice a day for 5 days.
The effect of clonidine on norepinephrine is due to inhibition release of neurotransmitter norepinephrine by activation of presynaptic α_2-adrenoreceptor axon terminal result in the increase of norepinephrine in brain.
The decreasing of catecholamine content in brain results in attenuation of the role of clonidine by pretreatment imipramine or tranylcypromine in rats. Catecholamine content in adrenal glands of rats were not significantly affected by clonidine, imipramine and tranylcypromine.
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